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目的探讨出生顺序与肝癌发生的关系,初步估计环境因素与遗传因素在肝癌发生的相对作用。方法应用Haldan-Sm ith法和G reenwood-Yu le法对81例肝癌患者及其同胞进行出生顺序分析。结果用Haldan-Sm ith法分析81例肝癌患者的出生顺序,6A实际值=1 362,6A期望值=1 515,t值=1.89,P>0.05;对肝癌先证者按HB sAg携带状态进行分层分析,HB sAg阳性者t值=2.20,P<0.05;HB sAg阴性者的t值=0.34,P>0.00;用G reen-wood-Yu le法比较肝癌患者出生顺序的实际分布和期望分布,显示两者无明显差别,实际数与期望数的比值为0.67~1.35,没有随出生顺序而增加或降低的趋势;按肝癌先证者HB sAg携带状态进行分层分析,HB sAg阴性者实际分布与期望分布均无明显差别,实际数与期望数的比值均未随出生顺序呈现增加或减小的趋势;HB sAg阳性者实际数与期望数的比值有随出生顺序呈现出减小的趋势。表明HB sAg阳性者肝癌的发生与出生顺序有关。结论HB sAg阳性者肝癌组中,环境因素的作用较遗传因素对肝癌的发生可能更重要;而HB sAg阴性者肝癌组中,遗传因素的作用较环境因素对肝癌的发生中可能更重要。
Objective To investigate the relationship between birth order and the occurrence of hepatocellular carcinoma and to estimate the relative role of environmental factors and genetic factors in the occurrence of hepatocellular carcinoma. Methods Haldan-Sm ith method and G reenwood-Yu le method for 81 cases of liver cancer patients and their siblings birth order analysis. Results The birth sequence of 81 patients with HCC was analyzed by Haldan-Smith method. The actual value of 6A was 1 362, the expected value of 6A was 1 515, the value of t was 1.89, P 0. 05. The percentage of HBsAg- T = 2.20, P <0.05; t value of HB sAg negative = 0.34, P> 0.00; The actual distribution and expected distribution of liver cancer patients by G reen-wood-Yu le method were compared , Showing no significant difference between the two, the ratio between the actual number and the expected number of 0.67 ~ 1.35, did not increase or decrease with the order of the birth trend; according to liver cancer proband HB sAg carrier state stratified analysis, HB sAg negative actually There was no significant difference between the distribution and the expected distribution, the ratio of the actual number and the expected number did not increase or decrease with the birth order; the ratio of the actual number and the expected number of HBsAg positive patients showed a decreasing trend with the birth order . That HB sAg positive occurrence of liver cancer and birth order. Conclusion The effect of environmental factors may be more important than that of hereditary factors on the occurrence of HCC in HBsAg-positive HCC patients. However, the effect of genetic factors may be more important than that of environmental factors in HCCs.