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大鼠腹主动脉部分狭窄５周后，形成实验性心肌肥厚模型，心肌和左心室重量明显增加，心肌过氧化脂质（ＬＰＯ）含量显著增加，ＳＯＤ活性下降，心肌和主动脉Ｃａ~（２＋）含量明显增加。给槲皮素７５、１５０ ｍｇ／ｋｇ后均能明显降低心肌和左心室重量，降低心肌ＬＰＯ含量，增加ＳＯＤ活性，降低心肌和主动脉Ｃａ~（２＋）的含量，提示槲皮素抗心肌肥厚作用与清除氧自由基和钙拮抗有关。
After partial stenosis of abdominal aorta in rats for 5 weeks, an experimental myocardial hypertrophy model was established. The myocardial and left ventricular weights were significantly increased, the content of myocardial lipid peroxide (LPO) was significantly increased, SOD activity was decreased, and myocardial and aortic Ca~(2+) ) The content has increased significantly. After quercetin 75 and 150 mg/kg, the myocardial and left ventricular weights were significantly decreased, the myocardial LPO content was decreased, SOD activity was increased, and the myocardial and aortic Ca~(2+) levels were decreased, suggesting that quercetin anti-cardiac hypertrophy The effect is related to the clearance of oxygen free radicals and calcium antagonism.