【摘 要】
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Our previous investigation suggested that faster seventh cervical nerve(C7)regeneration occurs in patients with cerebral injury undergoing contralateral C7 transfer.This finding needed further verification,and the mecha-nism remained largely unknown.Here,
【机 构】
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Department of Hand Surgery,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai 20004
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Our previous investigation suggested that faster seventh cervical nerve(C7)regeneration occurs in patients with cerebral injury undergoing contralateral C7 transfer.This finding needed further verification,and the mecha-nism remained largely unknown.Here,Tinel\'s test revealed faster C7 regeneration in patients with cerebral injury,which was further confirmed in mice by electro-physiological recordings and histological analysis.Further-more,we identified an altered systemic inflammatory response that led to the transformation of macrophage polarization as a mechanism underlying the increased nerve regeneration in patients with cerebral injury.In mice,we showed that,as a contributing factor,serum amyloid protein A1(SAA1)promoted C7 regeneration and inter-fered with macrophage polarization in vivo.Our results indicate that altered inflammation promotes the regenera-tive capacity of the C7 nerve by altering macrophage behavior.SAA1 may be a therapeutic target to improve the recovery of injured peripheral nerves.
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