本文报告了应用卟啉类光敏剂PSD—007和氩离子(Ar+)激光对13例消化道癌患者进行术中及术后标本萤光分布的观察结果。13例癌灶中12例检出橙红色萤光。26个癌切缘的萤光检测结果中24个与病理诊断相符。提示:PSD—007具有在消化道癌组织中的定位能力。萤光检测有助于显示癌灶的部位及浸润范围,故可望成为术中检测癌切缘的一个手段。此法安全、毒副反应小。但萤光检测的方法学和假阳性等问题尚需进一步探讨。 This paper reports the observation of fluorescence distribution of intraoperative and postoperative specimens in 13 patients with gastrointestinal cancer using porphyrin photosensitizers PSD-007 and argon ion (Ar+) lasers. Thirteen of 13 cancer foci were detected with orange-red fluorescence. Twenty-four of the twenty-six cancerous marginal fluoroscopic findings were consistent with pathological diagnosis. Tip: PSD-007 has the ability to localize in gastrointestinal cancer. Fluorescent detection helps to show the location and extent of invasion of cancer foci, so it is expected to be a means of detecting cancer margins during surgery. This method is safe and has few side effects. However, the methods and false positives of fluorescent detection need further investigation.