利尿剂和肾上腺素能阻滞剂广泛用于高血压病的治疗。最近的研究表明,噻嗪类、氯噻酮对脂质代谢具有不良影响,速尿对胆固醇比值亦有不利影响,而β阴滞剂则能增加甘油三酯或降低HDL,导致不利的胆固醇比值,但α_1肾上腺素能阻滞剂哌唑嗪却对脂质各成分无不良影响。利尿剂:Grimm等最近证明,双氢克尿噻和氯噻酮能增加轻型高血压病患者的血浆甘油三酯及总胆固醇,而且这种影响可以用低饱和脂肪和高多 Diuretics and adrenergic blockers are widely used in the treatment of hypertension. Recent studies have shown that thiazides and chlorthalidone have adverse effects on lipid metabolism and furosemide has an adverse effect on the cholesterol ratio, whereas β-blockers increase triglycerides or decrease HDL leading to an adverse cholesterol ratio , But α_1 adrenergic blocker prazosin has no adverse effects on the lipid components. Diuretics: Grimm et al. Have recently demonstrated that hydrochlorothiazide and chlorthalidone increase plasma triglycerides and total cholesterol in patients with mild-to-high Hypertension, and this effect can be attributed to lower saturated fat and higher