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色谱同时具有分离和分析的双重功能,因而被广泛应用于临床药物的分析,药物的临床标本主要有血(血浆、血清、全血)、尿、唾液及各种组织,其特点为(1)被测组分含量极微而采样量受到限制,大体积样品会带来灾难性的杂质干扰;(2)干扰杂质含量高而且成分复杂;(3)被测物质常出现同系物形式,或者为一系列代谢产物。在进入色谱系统前要对样品进行预处理,除去干扰物质和对色谱系统具有致命性损害的“脏”物质。在这方面药物工作者进行了
Chromatography also has the dual function of separation and analysis. It is widely used in the analysis of clinical drugs. The clinical samples mainly include blood (plasma, serum and whole blood), urine, saliva and various tissues, and are characterized by (1) The content of the tested components is very small and the sample size is limited. Large-volume samples will bring catastrophic impurity interference. (2) The content of the interfering impurities is high and the composition is complicated. (3) The tested substances often appear in the form of homologues or A series of metabolites. Samples are pretreated before entering the chromatographic system to remove interfering substances and “dirty” substances that are fatal to the chromatographic system. Drug workers are in this area