论文部分内容阅读
据Laurent LC 2011年1月7日[Cell Stem Cell,2011,8(1):106-118]报道,美国加州大学圣地亚哥分校医学院及斯克里普斯研究所的干细胞科学家领导的跨国研究团队,记录了在人类胚胎干细胞(hESC)和诱导功能干细胞(iPSC)系中特殊的基因畸变。它的发现强调了需要对多能干细胞进行频繁的基因检测,以保证其稳定性和临床安全性。研究者认为,人类多能干细胞(hESC和iPSC)比其他类型细胞有更高的基因畸变的频率。与其他非多能干细胞样本相比较,研究人员观察到hESC的基因扩增和iPSC的缺失方面出现的频率更高。
According to Laurent LC, January 7, 2011 [Cell Stem Cell, 2011, 8 (1): 106-118] reported that multinational research teams led by stem cell scientists at the University of California San Diego School of Medicine and the Scripps Research Institute, The special gene aberrations in human embryonic stem cells (hESCs) and induced functional stem cells (iPSC) lines were documented. Its findings underscore the need for frequent genetic testing of pluripotent stem cells to ensure their stability and clinical safety. Researchers believe that human pluripotent stem cells (hESC and iPSC) have a higher frequency of genetic aberrations than other types of cells. Compared with other non-pluripotent stem cell samples, the researchers observed a higher frequency of hESC gene amplification and iPSC deletion.