论文部分内容阅读
目的观察普萘洛尔口服治疗婴幼儿血管瘤的临床疗效及安全性。方法选择2011年3月-2012年4月本科住院的50例婴幼儿血管瘤于心电监护下予口服普萘洛尔治疗,男18例,女32例,平均年龄4个月,治疗前完善相关实验室检查,每月复查1次,并根据体重增减情况调整用药剂量,至皮损消退后减量并停药。结果 50例患儿在用药后24h内即出现瘤体颜色变浅、质地变软或缩小。有效率为80%,其中Ⅰ级0例(差),Ⅱ级10例(中),Ⅲ级25例(好),Ⅳ级15例(优),用药时间延长,治疗效果越明显(P<0.05)。平均用药时间5个月(2～13个月),停药时间平均年龄8个月(5～27个月)。合并溃疡者,溃疡愈合时间平均9d(7～15d)。不良反应轻微,主要表现为消化道症状。结论普萘洛尔口服治疗婴幼儿血管瘤临床疗效明显,安全性好,可作为婴幼儿血管瘤的一线治疗用药。
Objective To observe the clinical efficacy and safety of oral propranolol in infantile hemangiomas. Methods From March 2011 to April 2012, 50 infants and young children with hemangiomas undergoing hospitalization were treated with propranolol under ECG. There were 18 males and 32 females, with an average age of 4 months. Before treatment, Relevant laboratory tests, review once a month, and adjust the dose according to weight gain and decrease to skin lesions subsided and withdrawal. Results 50 cases of children within 24 hours after treatment that appear lighter color of the tumor, the texture becomes soft or reduced. The effective rate was 80%. There were 0 cases in grade Ⅰ, 10 cases in grade Ⅱ, 25 cases in grade Ⅲ and 15 cases in grade Ⅳ. The longer the treatment time was, the more effective the treatment was (P < 0.05). The average medication time of 5 months (2 to 13 months), withdrawal time average age of 8 months (5 to 27 months). Combined ulcer, ulcer healing time average 9d (7 ~ 15d). Minor adverse reactions, mainly as gastrointestinal symptoms. Conclusion Propranolol oral treatment of infantile hemangiomas clinical effect is obvious, safe, can be used as first-line treatment of infantile hemangiomas medication.