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目的：探讨慢性低氧脾组织的病理学改变。方法：将Ｗｉｓｔａｒ大鼠喂养在逐渐降低的常压低氧条件下，用氮气和空气的混合气体调节氧含量，氧浓度由常含量逐步降低为１５％，１２％，１０％，８％，最后降为７％，实验共进行１１２天。结果：低氧大鼠体重下降，脾重增加，红髓增生，脾血管壁增厚，脾内出现较多泡沫细胞。白髓减少，脾小体萎缩或消失。结论：长期慢性严重低氧可导致脾脂质沉积，免疫能力下降。
Objective: To investigate the pathological changes of chronic hypoxia spleen. Methods: The Wistar rats were fed with decreasing atmospheric pressure and hypoxia, and the oxygen content was adjusted by mixed gas of nitrogen and air. The oxygen concentration was gradually reduced from the normal content to 15%, 12%, 10%, 8% Reduced to 7%, the experiment conducted a total of 112 days. Results: Hypoxic rats decreased body weight, spleen weight, red pulp hyperplasia, splenic wall thickening, more foam cells in the spleen. White pulp decreased spleen body atrophy or disappear. Conclusion: Long-term chronic severe hypoxia can lead to the deposition of spleen lipids and decrease the immunity.