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目的：分析冠状动脉支架置入术后支架内再狭窄的影响因素，为临床预防再狭窄提供理论支持。方法：回顾性分析自2011年3月至2013年9月在我院行冠脉支架置入术，并于术后1年行冠脉造影随访的123例患者的临床资料。以置入支架内径狭窄≥50％为再狭窄，分为再狭窄组（35例）和无再狭窄组（88例）。采用多因素Logistic回归分析分析冠脉支架内再狭窄的影响因素。结果：与无再狭窄组比较，再狭窄组血清总胆红素水平[（14.02±6.76）μmol／L比（10.90±4.51）μmol／L]显著降低、支架直径[（3.06±0.86） mm比（2.87±0.44） mm]显著减小， P均＜0.01。多因素 Logistic回归分析结果显示，血糖水平是冠状动脉支架术后再狭窄的独立危险因素（OR＝2.545， P＝0.035），而支架直径和血清总胆红素水平是其保护因素（OR＝0.857，0.850， P＝0.044，0.042）。结论：血糖水平是冠状动脉支架内再狭窄的危险因素，支架直径和血清总胆红素水平是其保护因素。“,”Objective:To analyze influencing factors of in‐stent restenosis after coronary artery stent implantation ,to provide theoretical support for clinical prevention of restenosis . Methods:Clinical data of 123 patients ,who re‐ceived coronary artery stent implantation in our hospital from Mar 2011 to Sep 2013 and received coronary angiogra‐phy follow‐up one year after operation ,were retrospectively analyzed .In‐stent restenosis was regarded as stenosis of inner diameter of implanted stent ≥50% ,so patients were divided into restenosis group (n=35) and non‐restenosis group (n=88) .Multi‐factor Logistic regression analysis was used to analyze influencing factors of coronary in‐stent restenosis .Results:Compared with non‐restenosis group ,there were significant reductions in serum level of total bilirubin [ (14.02 ± 6.76)μmol/L vs .(10.90 ± 4.51)μmol/L] and stent diameter [ (3.06 ± 0.86) mm vs .(2.87 ± 0.44) mm] in restenosis group , P<0.01 both .Multi‐factor Logistic regression analysis indicated that blood glucose level was independent risk factor for restenosis after coronary artery stent implantation (OR=2.545 , P=0.035) , while stent diameter and serum level of total bilirubin were its protective factors (OR=0. 857 , 0. 850 , P=0. 044 , 0.042) .Conclusion:Blood glucose level is an independent risk factor for restenosis after coronary artery stent im‐plantation ,while stent diameter and serum level of total bilirubin are its protective factors .