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本文评析了霍夫曼 (A· W· Hofmann)彻底甲基化反应的历程 ,反应举例。总结归纳出通过彻底甲基化在测定生物碱结构中的有关规律。
This article reviews the course of the thorough methylation reaction by Hofmann and gives examples of reactions. Summarizes the relevant laws of alkaloid structure through thorough methylation.