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PG对消化系统的生理作用及其临床意义介绍如下。一、前列腺素对消化系统的作用 1.唾液腺:动物试验证明,PGF_(2α)可促进唾液分泌,PGE_1无此作用;PGE_2有此作用,但很弱。PGF_(2α)之所以能使唾液分泌增加,可能是通过增加副交感神经末梢的乙酰胆碱的游离而起作用的。上述作用可被抗胆碱药物所抑制。 2.食管:贲门部括约肌(LES)弛缓不全的病因,以往认为和神经丛功能障碍以及胃泌素所致括约肌收缩增强或粘膜反射障碍有关。近来用PG合成阻滞剂(消炎痛),可引起LES收缩增强,从而分析该病与内源性PG产
The physiological role of PG on the digestive system and its clinical significance are described below. First, prostaglandins on the digestive system 1. Salivary gland: animal experiments show that, PGF_ (2α) can promote saliva secretion, PGE_1 no such effect; PGE_2 have this effect, but very weak. The reason why PGF_ (2α) can increase salivary secretion may play an important role in increasing the release of acetylcholine in the parasympathetic nerve endings. The above effects can be inhibited by anticholinergic drugs. 2. Esophagus: cardia sphincter (LES) flaccid etiology, in the past that the nerve plexus dysfunction and gastrin-induced sphincter contraction or mucosal reflex obstacles. Recently, PG synthesis blockers (indomethacin), can cause increased contractility of LES to analyze the disease and endogenous PG production