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我们用尼群地平（Ｎｉｔｒｅｎｄｉｐｉｎ）和氟尿嘧啶（５－Ｆｕ）或其衍生物呋喃氟尿嘧啶（ＦＴ─２０７）配伍，５μｇ／ｍｌ的Ｎｉｔｒ使５－Ｆｕ对Ｌ─１２１０细胞的体外杀伤力增加２．８倍（ＩＣ５０由０．７０μｇ／ｍｌ降至０．２５μｇ／ｍｌ），１０μｇ／ｍｌ的Ｎｉｔｒ使５－Ｆｕ对ＳＧＣ─７９０１细胞的杀伤力提高３．１倍（ＩＣ５０从１．２５μｇ／ｍｌ降至０．４１μｇ／ｍｌ）；ＦＴ─２０７联合２ｍｇ的Ｎｉｔｒ治疗小鼠肉瘤Ｓ─１８０使抑瘤率从３３％增至５７％（Ｐ＜０．００１）；高效液相色谱仪提示联合用药提高了肿瘤细胞内５－Ｆｕ的药物浓度（提高３２％）。试验结果证明钙通道阻滞剂Ｎｉｔｒ能提高抗代谢类抗肿瘤药物ＦＴ─２０７的抗肿瘤效应。
We used 5-Fu Nitrofurandone (5-Fu) or its derivative Furan Fluorouracil (FT ─207) compatibility, 5μg / ml Nitr 5-Fu on L ─ 1210 cells in vitro cytotoxicity increased by 2.8 (IC50 from 0.70μg / ml to 0.25μg / ml) and 10μg / ml Nitr increased the lethality of 5-Fu to SGC-7901 cells by 3.1-fold (IC50 decreased from 1.25μg / ml To 0.41μg / ml); FT-207 combined with 2mg of Nitr treatment of mouse sarcoma S ─ 180 increased the inhibitory rate from 33% to 57% (P <0.001); high performance liquid chromatography suggested a combination therapy Increased 5-Fu drug concentration in tumor cells (32% increase). The experimental results show that Nitr, a calcium channel blocker, can enhance the anti-tumor effect of anti-metabolite antitumor drug FT-207.