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在研究内毒素引起肿瘤出血性坏死时,发现经BCG免疫的小鼠用内毒素处理后在血清中含有肿瘤坏死因子(Tumor necrosis factor;TNF)。这种物质具有与内毒素相似的,能使肿瘤坏死的作用。在引起Meth A肉瘤和其他移植性肿瘤的坏死中,TNF阳性血清和内毒素有同样的效果。多种实验表明:TNF不是残余的内毒素,而是宿主细胞(可能是巨噬细胞)受内毒素作用后所释放的一种因子。棒状杆菌与酵母多糖象BCG一样,能促使网状内皮系统增生,因此,能代替BCG促使小鼠受内毒素作用后释放出TNF。
In the study of endotoxin-induced tumor hemorrhagic necrosis, mice immunized with BCG were found to contain Tumor necrosis factor (TNF) in their serum after treatment with endotoxin. This substance has endotoxin similar to tumor necrosis. TNF-positive sera have the same effect as endotoxin in causing necrosis of Meth A sarcoma and other transplanted tumors. Numerous experiments show that TNF is not a residual endotoxin, but a factor that is released by endotoxin after the host cell, which may be a macrophage. Corynebacteria and yeast polysaccharides, like BCG, can promote the proliferation of reticuloendothelial system, therefore, can replace the BCG to promote the release of TNF by the role of endotoxin in mice.