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目的：研究齐酞酸钠对大鼠实验性肝损伤的保护作用，并与齐墩果酸进行量效比较。方法：采用化学毒物Ｄ氨基半乳糖和四氯化碳致大鼠肝脏损伤，测定生化指标及观察病理组织学改变。结果：齐酞酸钠呈剂量依赖性地明显降低Ｄ氨基半乳糖、四氯化碳引起的大鼠血清丙氨酸转移酶（ＡＬＴ）增高；显著减轻肝脏中脂肪蓄积；病理组织学检查齐酞酸钠明显减轻肝细胞的变性和坏死。结论：齐酞酸钠对大鼠实验性肝损伤有明显的保护作用，在同等剂量下上述作用优于齐墩果酸。
OBJECTIVE: To study the protective effect of sodium phthalate on experimental liver injury in rats and to compare it with oleanolic acid in a dose-effect manner. Methods: Liver damage was induced by chemical poison D-galactosamine and carbon tetrachloride. The biochemical indexes and pathological changes were observed. Results: Sodium phthalate significantly decreased D-galactosamine in a dose-dependent manner, increased serum levels of alanine aminotransferase (ALT) in rats induced by carbon tetrachloride, significantly reduced fat accumulation in the liver, and histopathological examination Sodium phthalate significantly reduces hepatocyte degeneration and necrosis. CONCLUSION: Sodium azide has a significant protective effect on experimental liver injury in rats, which is superior to oleanolic acid at the same dose.