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心肌肥厚是心肌组织超负荷的一种代偿性反应，以心肌细胞蛋白质合成增加、心肌细胞体积增大及间质成分改变为主要特征，是引起多种心血管疾病发病率和病死率升高的独立危险因素之一。心肌肥厚的发生机制极其复杂，可能存在一个复杂的促进心肌肥厚网络。虽然历经多年研究，心肌肥厚的机制至今尚未完全明了。心肌肥厚的发生与机械性、神经体液、内分泌、交感神经系统活性、细胞因子、基因以及一氧化氮等多种因素相关。该文就心肌肥厚发生的机制及相应药物治疗的研究概况进行阐述。“,”Myocardial hypertrophy is a compensatory response to myocardial tissue overload,with themain characteristics of protein synthesis increase,myocardial cell volume enlargement and the mesenchymalcomponents changes.It is one of the independent risk factors raising cardiovascular disease morbidity andmortality.The mechanism of cardiac hypertrophy is extremely complex, and a complex network may promotecardiac hypertrophy development.So far the mechanism of myocardial hypertrophy is still unclear, a variety offactors may be involved,such as mechanical factors,neurohormonal factors,endocrine factors, sympatheticnervous system activity, cytokine,gene,nitric oxide and so on.Here is to make a review of the mechanismand its corresponding medication of cardiac hypertrophy.