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为了解乙型肝炎血源疫苗的免疫持久性，对３４４例小学生追踪随访，并采集血标本，以ＡｂｂｏｔＲＩＡ法检测ＨＢｓＡｇ、抗－ＨＢｃ和抗－ＨＢｓ。第七年时，抗－ＨＢｓ≥１０ＩＵ／Ｌ者为５５．４％～７５．０％，ＧＭＴ为２０．９～６５．３ＩＵ／Ｌ；抗－ＨＢｓ滴度越高，下降至１０ＩＵ／Ｌ以下的时间越长；免疫后７年时，对６６例抗－ＨＢｓ不同滴度者给予第４针（１０μｇ）疫苗后１月，抗－ＨＢｓ升高６．３～５７．７倍。说明儿童接种乙型肝炎血源疫苗后７年内可不必加强接种。
To understand the immune persistence of Hepatitis B virus vaccine, 344 primary school students were followed up and blood samples were taken for detection of HBsAg, anti-HBc and anti-HBs by AbbotRIA. At the seventh year, the anti-HBs≥10 IU / L were 55.4% -75.0%, GMT was 20.9-65.3 IU / L; the higher the anti-HBs titer, down to below 10 IU / L The longer the time was, the 7th year after immunization, anti-HBs were increased by 6.3-57.7 times in January after giving the fourth needle (10μg) vaccine to 66 patients with different titres of anti-HBs. Shows that children vaccinated with hepatitis B blood vaccine after 7 years may not need to step up vaccination.