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目的:探讨不同剂量的血管紧张素转化酶抑制剂对急性心肌梗死患者P波离散度(Pd)、最大P波时限(Pmax)及住院期间心房颤动(Af)发生率的影响。方法:选择我院2005-10-2007-12间因急性心肌梗死住院治疗的患者共263例,平均住院时间14·6d,采用贝那普利干预,观察不同剂量的贝那普利对患者Pd、Pmax及住院期间Af发生率的影响。结果:2组患者治疗前Pmax[(96·67±15·71)ms∶(94·41±13·79)ms,P>0·05]、Pd[(52·13±9·87)ms∶(55·56±10·21)ms,P>0·05]无明显差别;大剂量贝那普利治疗组2周后Pmax[(96·67±15·7)ms∶(87·89±9·31)ms,P<0·05]、Pd[(52·13±9·87)ms∶(46·62±7·22)ms,P<0·05]明显减小,而小剂量组治疗前后Pmax[(94·41±13·79)ms∶(93·78±14·16)ms]、Pd((55·56±10·21)ms∶(51·08±9·34)ms]有下降的趋势,但差异无统计学意义。大剂量治疗组住院期间Af的发生次数较小剂量治疗组明显减少。结论:大剂量贝那普利较小剂量贝那普利能更明显减小Pd、Pmax,同时减少住院期间Af的发生。
Objective: To investigate the effects of different doses of angiotensin converting enzyme inhibitors on P wave dispersion, maximum P wave length (Pmax) and incidence of atrial fibrillation (Af) in hospitalized patients with acute myocardial infarction. Methods: A total of 263 hospitalized patients with acute myocardial infarction in our hospital from October 2005 to December 2007 were selected. The average length of hospital stay was 14.6 days. The benazepril intervention was used to observe the effects of different doses of benazepril on patients with Pd , Pmax and incidence of Af during hospitalization. Results: Before treatment, Pmax (96.67 ± 15.71) ms (94.41 ± 13.79) ms, P> 0.05, Pd [(52.13 ± 8.787) ms : (55 · 56 ± 10 · 21) ms, P> 0.05 · No significant difference; high-dose benazepril treatment group 2 weeks after Pmax [(96.67 ± 15.7) ms: (87.89 ± 9 · 31) ms, P <0 · 05], Pd [(52 · 13 ± 9 · 87) ms: (46 · 62 ± 7 · 22) ms, P <0 · 05] Pmax [(94.41 ± 13.79) ms vs (93.78 ± 14.16) ms], Pd (55.56 ± 10.21) ms: (51.08 ± 9.34) ) ms], but there was no significant difference between the two groups.The incidence of Af in the high-dose treatment group was significantly lower than that in the lower dose treatment group.Conclusion: The high-dose benazepril can lower the dose of benazepril Significantly reduce Pd, Pmax, while reducing the incidence of Af during hospitalization.