随着短寿命核素标记的需要,当前世界各国正在不断地发展各种快速简易的标记方法,近年来在熔融标记法的基础上正在探索一种新的快速交换法——热液熔融法(HydrothermalMelt Method)。本文研究了热液熔融法在胆固醇、玫瑰红、马尿酸和脂肪酸四种放射性药物标记中的应用并讨论了在热液熔融状态下,复相同位素交换反应的动力学规律,实验结果表明: With the need of short-lived nuclide labeling, various countries in the world are constantly developing various rapid and easy marking methods. In recent years, based on the melt marking method, a new rapid exchange method-hydrothermal fusion method HydrothermalMelt Method). In this paper, the application of hydrothermal melting method in the labeling of cholesterol, rosebud, hippuric acid and fatty acid radiopharmaceuticals was studied. The kinetics of the complex isotope exchange reaction in hot melt was discussed. The experimental results show that: