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目的 :研究胃癌组织及相应癌旁组织中的端粒酶活性 ,探讨其作为胃癌肿瘤标记物的可能性。方法 :采用PCR -ELISA方法检测 36例胃癌组织及 36例相应癌旁组织中端粒酶活性的表达。结果 :36例胃癌组织中 ,30例端粒酶呈阳性 ,阳性率为 83 3% ;而 36例癌旁组织中只有 1例阳性。结论 :端粒酶是特异性较强的恶性肿瘤基因标志 ,有可能成为胃癌早期诊断的理想标志物。
Objective: To study the telomerase activity in gastric cancer tissues and corresponding paracancerous tissues and to explore its potential as a tumor marker for gastric cancer. Methods: The telomerase activity was detected by PCR-ELISA in 36 cases of gastric cancer and 36 cases of paracancerous tissues. Results: Thirty cases of 36 gastric cancer tissues were positive for telomerase, with a positive rate of 83.3%. Only 1 of 36 paracancerous tissues was positive. Conclusion: Telomerase is a specific marker of malignant tumor, which may be an ideal marker for the early diagnosis of gastric cancer.