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目的 :探讨子宫内膜粘液癌中雌激素受体 (ER)和癌胚抗原 (CEA)免疫组化表达及其意义。方法 :采用免疫组化S P方法对 5例子宫内膜粘液癌 ,12例普通型子宫内膜癌及 5例子宫颈粘液癌作ER、CEA、vimentin(波形蛋白 )及c erbB 2 (原癌基因 )免疫标记。结果 :子宫内膜粘液癌ER阴性 (0 / 5 ) ,CEA阳性表达 (4/ 5 ) ,与普通型子宫内膜癌ER高表达及CEA低表达差异均有显著性 (P <0 .0 5～P <0 .0 0 5 )。子宫内膜粘液癌vimentin高表达与子宫颈粘液癌不表达之间差异也有显著性 (P <0 .0 0 5 )。结论 :子宫内膜粘液癌缺乏ER ;vimentin有助于鉴别子宫内膜与子宫颈的粘液癌。
Objective: To investigate the immunohistochemical expression of estrogen receptor (ER) and carcinoembryonic antigen (CEA) in endometrial mucinous carcinoma and its significance. Methods: The expressions of ER, CEA, vimentin (vimentin) and c erbB 2 (protooncogenes) in 5 cases of endometrial mucinous carcinoma, 12 cases of common endometrial carcinoma and 5 cases of cervical mucinous carcinoma were detected by immunohistochemical SP method. Immune labeling. Results: The positive rate of ER (0/5), CEA (4/5) in endometrial mucinous carcinoma was significantly higher than that in common endometrial carcinoma and low CEA (P <0.05) ~ P <0 0 0 5). There was also a significant difference between high expression of vimentin and non-expression of cervical mucinous carcinoma in endometrial mucinous carcinoma (P <0.05). Conclusion: Endometrial mucinous carcinoma lacks ER; vimentin helps identify endometrial and cervical mucinous carcinomas.