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目的:分析我院药品不良反应(ADR)发生的特点和相关因素,为临床合理用药提供参考。方法:对我院2009年9月-2011年10月所收集的390例ADR报告进行回顾性分析。结果:在390例ADR报告中,女性(236例)多于男性(154例),以≥50岁的中老年人与≤18岁的未成年人发生率居高。在给药方式中,静脉滴注引发的ADR最多(占86.67%)。在ADR涉及的药品种类及例/次中,抗菌药物居首位(占70.00%),其次是中药及中药制剂(占11.03%)。ADR临床表现以皮肤及其附件损害最为常见(占41.79%)。结论:我院ADR的发生与患者性别、年龄、给药途径、药品种类等相关;临床应加强合理使用抗菌药物及中药注射剂,以减少和避免ADR的发生。
Objective: To analyze the characteristics and related factors of adverse drug reaction (ADR) in our hospital and provide references for clinical rational drug use. Methods: A retrospective analysis of 390 ADRs collected in our hospital from September 2009 to October 2011 was performed. RESULTS: Of the 390 ADR cases, there were more women (236 cases) than men (154 cases), with a high prevalence of ≥50 years of middle-aged and older adults ≤18 years of age. In the mode of administration, intravenous infusion caused the most ADR (86.67%). Antibiotics ranked the top (70.00%) among the types and cases of drugs involved in ADR, followed by traditional Chinese medicine and traditional Chinese medicine preparations (11.03%). The clinical manifestations of ADR damage to the skin and its accessories the most common (41.79%). Conclusions: The incidence of ADR in our hospital is related to patient’s gender, age, route of administration, drug type, etc. The clinical use of antimicrobial agents and traditional Chinese medicine injections should be strengthened to reduce and avoid the occurrence of ADR.