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目的:分析妇女人乳头瘤病毒(HPV)的感染状况、亚型分布以及与宫颈疾病的关系。方法:选取3 427例妇女为研究对象,使用HC-2的检验方式对受检者进行宫颈刮片行HPV检测,并对HPV感染率、型别分布及其与宫颈疾病的相关性进行分析。结果:普查受检者中共检测986例阳性标本,HPV阳性率为28.77%,高危型阳性614例(17.92%),以HPV16、58、52、33、56亚型为主;低危型293例(8.55%),以HPV6、11亚型为主;其他型79例(2.31%),以HPVCP8304、53亚型为主。HPV感染率随年龄增长呈下降趋势,HPV感染与宫颈病变严重程度与呈正相关。结论:HPV感染在宫颈病变中起重要作用,与宫颈癌的发生存在相关性,HPV检测对宫颈恶性病变的早期发现和治疗预防有重要价值。
Objective: To analyze the infection status, subtypes and the relationship with cervical diseases in women with human papillomavirus (HPV). Methods: A total of 3 427 women were enrolled in this study. The HC-2 test was used to detect HPV in cervical smears. The HPV infection rate, type distribution and the correlation with HPV were analyzed. Results: 986 positive specimens were detected in the census subjects, the positive rate of HPV was 28.77%, the high-risk type was 614 (17.92%), mainly HPV16, 58, 52, 33 and 56 subtypes; (8.55%), HPV6,11 subtype is the main type; the other 79 cases (2.31%), mainly HPVCP8304,53 subtype. HPV infection rate decreased with age, HPV infection and the severity of cervical lesions and was positively correlated. Conclusion: HPV infection plays an important role in cervical lesions, which is correlated with the occurrence of cervical cancer. HPV detection has important value in the early detection and treatment of cervical malignant lesions.