二氧化矽能毒害巨噬细胞已成为众所周知的事实。有许多实验都证明巨噬细胞在吞噬石英后,它的某些胞内酶活性下降并逸出,而另一些酶如磷脂酶 A 反被激活。本文作者观察了大鼠腹腔巨噬细胞在吞噬石英或其它毒性粉尘的过程中磷脂和脂肪代谢的变化;这一工作的结果可为探讨粉尘与巨噬细胞膜及膜内物质相互作用并导致巨噬细胞死亡的机制提供新资料。 It has become a well-known fact that silicon dioxide can poison macrophages. There are many experiments that demonstrate that after phagocytosis of quartz by macrophages, some of its intracellular enzyme activities decrease and escape, while others, such as phospholipase A, are activated. The authors observed changes in phospholipid and fat metabolism during phagocytosis of quartz or other toxic dusts by rat peritoneal macrophages; the results of this work may be to explore the interaction of dust with macrophage membrane and membrane substances and lead to macrophages Mechanisms of cell death provide new information.