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目的：为了摸清流行性出血热病毒在人体及各种动物组织中的形态分布及所致病变．方法：作者以多克隆抗体及抗Ｇ２，ＮＰ及血凝素等单克隆抗体，用多重ＰＡＰ等免疫组织化学方法。结果：证明人、大鼠及小鼠体内均存在可溶性及颗粒性两种抗原．在人体尸检病例、骨髓穿刺标本、大鼠及小鼠用多克隆抗体及某些单克隆抗体，均可显示包涵体样颗粒性抗原阳性物质，它在电镜下多位于核旁或高尔基体旁呈扩大的泡状或实体状．结论：颗粒抗原阳性细胞可呈增生及变性坏死两种类型的变化，应属病毒或相应因素引起的原发性病变．包涵体本身就是一种病变．
Objective: In order to find out the epidemic hemorrhagic fever virus in human and various animal tissues in the morphological distribution and pathological changes. Methods: The authors used polyclonal antibodies and anti-G2, NP and hemagglutinin monoclonal antibodies, with multiple PAP and other immunohistochemical methods. Results: It is proved that both soluble and granular antigens exist in human, rat and mouse. In the human autopsy cases, bone marrow puncture specimens, polyclonal antibodies in mice and mice and some monoclonal antibodies, can show inclusion body-like particle antigen-positive substances, which are located in the electron microscope next to the nucleus or the Golgi apparatus Expanded bubble or solid shape. Conclusion: Granulocyte antigen positive cells may present two types of changes, such as hyperplasia and degeneration and necrosis, which should be caused by viruses or corresponding factors. Inclusion itself is a kind of disease.