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为了探讨乙醇性胃粘膜损伤和牛磺酸对其保护作用的机制，将４０只ＳＤ大鼠分为对照组、乙醇损伤组和牛磺酸保护组，观察其胃粘膜中内皮素（ＥＴ）、一氧化氮合成酶（ＮＯＳ）、生长抑素（ＳＳ）和血管活性肠肽（ＶＩＰ）的变化。结果如下：（１）随着乙醇作用时间延长、粘膜的损伤加重，胃粘膜内ＥＴ含量显著上升，而ＮＯＳ、ＳＳ和ＶＩＰ含量显著下降；（２）牛磺酸可显著减轻乙醇性胃粘膜损伤，抑制ＥＴ释放，增加ＮＯＳ活性和ＳＳ、ＶＩＰ的含量。上述结果表示，ＥＴ、ＮＯＳ、ＳＳ和ＶＩＰ的变化参与了乙醇性胃粘膜损伤的病理生理过程；牛磺酸对乙醇性胃粘膜损伤具有保护作用，可能与其调节胃粘膜内ＥＴ、ＮＯＳ、ＳＳ和ＶＩＰ的释放与活性有关。
In order to investigate the mechanism of ethanol-induced gastric mucosal injury and the protective effect of taurine, 40 SD rats were divided into control group, ethanol-injured group and taurine protective group. Endothelin (ET) Changes of nitrogen synthase (NOS), somatostatin (SS) and vasoactive intestinal peptide (VIP). The results were as follows: (1) With the prolongation of ethanol time, the damage of mucosa was aggravated. The contents of ET in gastric mucosa significantly increased, while the content of NOS, SS and VIP decreased significantly. (2) Taurine could significantly reduce the damage of alcoholic gastric mucosa , Inhibit ET release, increase NOS activity and SS, VIP content. The above results indicate that the changes of ET, NOS, SS and VIP are involved in the pathophysiological process of ethanol-induced gastric mucosal injury. Taurine has a protective effect on ethanol-induced gastric mucosal injury, which may be related to its regulation of ET, NOS, SS and VIP release and activity.