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由于息斯敏有潜在的威胁生命的药品相互作用,因而美国 FDA 于1992年10月批准修改息斯敏的说明书。修改后的说明书中,由于可能有不良的心脏反应,禁止息斯敏与抗霉菌药酮康唑和伊曲康唑(Itraconazole)或大环内酯抗生素红霉素同时使用。
Because Astemizole has potentially life-threatening drug interactions, the FDA approved a change of aspartame’s specification in October 1992. In the revised specification, aspartame is prohibited from being used concurrently with the antimycotic ketoconazole and itraconazole or the macrolide antibiotic erythromycin because of possible adverse cardiac reactions.