侵袭性NK细胞淋巴瘤(ANKL)是一种系统性NK细胞肿瘤,与EB病毒(EBV)有关。EBV阴性的ANKL临床罕见,且提示具有惰性的生物学行为。作者报道7例EBV阴性ANKL的临床病理、免疫表型及分子遗传学特征。7例均为成人,年龄22~83岁,中位年龄63岁;男∶女为2.5∶1; Invasive NK cell lymphoma (ANKL) is a systemic NK cell tumor associated with Epstein-Barr virus (EBV). EBV-negative ANKL is clinically rare and suggests an inert biological behavior. The authors report 7 cases of EBV-negative ANKL clinical pathology, immunophenotype and molecular genetics. 7 cases were all adults, aged 22 to 83 years old, the median age of 63 years; men: women 2.5: 1;