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癫痫的患病率在我国约为4.75‰,是常见多发病之一。迄今为止其治疗手段仍以抗癫瘸药物(AED)为主。但以单药还是多种药物联合治疗为宜,仍有争议。在癫痫发作的类型中,全身强直-阵挛发作(大发作)与部分性发作最为多见。一般常用苯妥英钠(DPH),苯巴比妥(PB)、卡马西平(CBZ)、扑痫酮(PR)与丙戊酸钠(VA)等,其中尤以DPH与PB多用。治疗上述二种发作时常合用DPH与PB或再加上其他药物。我们就近3年来在DPH、CBZ血清浓度监测下,对289例病人的AED疗效进行了分析。
The prevalence of epilepsy in our country is about 4.75 ‰, is one of the common frequently-occurring disease. So far the treatment is still anti-epilepsy drugs (AED) -based. However, single drug or multi-drug combination therapy is appropriate, there are still controversies. Among the types of seizures, generalized tonic-clonic seizures (major episodes) and partial seizures are the most common. Commonly used phenytoin sodium (DPH), phenobarbital (PB), carbamazepine (CBZ), epilepsy ketone (PR) and sodium valproate (VA), especially in DPH and PB multi-purpose. Treatment of the above two seizures often combined with DPH and PB or with other drugs. We have analyzed the efficacy of AED in 289 patients under the surveillance of serum concentrations of DPH and CBZ for the past three years.