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血小板聚集在血栓形成过程中发挥关键作用,抗血小板药物是预防和治疗动脉粥样硬化疾病患者发生严重心血管事件的重要基石。P2Y12受体拮抗剂是一类重要的抗血小板药物,近年来成为研究的热点并在临床上广泛应用。本文结合最新研究进展,对P2Y12受体拮抗剂作用机制、药理学特征、临床疗效及安全性进行综述,以期为临床合理用药提供参考。
Platelet aggregation plays a key role in thrombosis and antiplatelet drugs are important cornerstones in the prevention and treatment of severe cardiovascular events in patients with atherosclerotic disease. P2Y12 receptor antagonist is an important class of antiplatelet drugs, which has become a hot spot in recent years and widely used clinically. In this paper, the latest research progress, P2Y12 receptor antagonist mechanism of action, pharmacological characteristics, clinical efficacy and safety review, in order to provide a reference for clinical rational use of drugs.