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A numerical analysis of natural convection of nanofluid in a wavy-walled enclosure with an isothermal cer heater has been carried out. The cavity is heated from the left bottom cer and cooled from the top wavy wall while the rest walls are adiaba- tic. Mathematical model has been formulated using the single-phase nanofluid approach. Main efforts have been focused on the effects of the dimensionless time, Rayleigh number, undulation number, nanoparticle volume fraction and length of cer heaters on the fluid flow and heat transfer inside the cavity. Numerical results have been presented in the form of streamlines, isotherms, velocity and temperature profiles, local and average Nusselt numbers. It has been found that nanoparticle volume fraction essentially affects both fluid flow and heat transfer while undulation number changes significantly only the heat transfer rate.