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目的:评价平阳霉素注射治疗舌下腺囊肿的临床效果。方法:1997年1月—2009年1月,应用平阳霉素及地塞米松混合液注射治疗舌下腺囊肿785例。采用DXM 5mg/1mL配PYM 8mg加2%利多卡因3mL,按每1cm×1cm的囊肿内注入1mL混合药液(含PYM 2mg,DXM 1.25mg)酌情用药。7～10d注射1次,1～4次为1个疗程。囊肿完全消失者为治愈;囊肿基本消失,但患侧可触及变硬舌下腺者为基本治愈;囊肿缩小一半以上,不能完全消失需手术治疗者为好转。结果:785例患者中,男270例,女515例,年龄7个月～74岁,平均年龄为33.5岁。经6个月～48个月随访,治愈756例(96.31%),基本治愈26例(3.31%),好转3例(0.38%)。治愈和基本治愈率为99.62%,有效率为100%。31例(3.95%)注射区肿痛,舌缘麻木21例(2.68%),下颌下区肿痛11例(1.4%);未见高热、皮疹、休克等过敏反应。结论:平阳霉素联合地塞米松注射治疗舌下腺囊肿,安全有效,可作为某些病例的首选治疗方法。
Objective: To evaluate the clinical effect of pingyangmycin injection in treating sublingual gland cyst. Methods: From January 1997 to January 2009, 785 cases of sublingual gland cysts were treated with bleomycin and dexamethasone. Using DXM 5mg / 1mL with PYM 8mg plus 2% lidocaine 2mL, per 1cm × 1cm cyst injected 1mL mixed liquid (containing PYM 2mg, DXM 1.25mg) discretion medication. 7 ~ 10d injection 1, 1 to 4 times for a course of treatment. Completely disappeared cysts were cured; cyst disappeared, but the affected side can reach the hardened sublingual gland are basically cured; cysts shrink more than half, can not completely disappear the need for surgical treatment for the improvement. Results: Of the 785 patients, 270 were male and 515 were female, ranging in age from 7 months to 74 years with a mean age of 33.5 years. After 6 months to 48 months of follow-up, 756 cases (96.31%) were cured, 26 cases (3.31%) were basically cured and 3 cases (0.38%) were cured. Healing and basic cure rate was 99.62%, the effective rate was 100%. There were 31 cases (3.95%) of the injected area with swelling pain, 21 cases of tongue margin numbness (2.68%) and 11 cases of submandibular swelling (1.4%). No hypersensitivity, rash and shock were observed. Conclusion: Pingyangmycin injection combined with dexamethasone injection of sublingual gland cyst is safe and effective, which can be used as the preferred treatment in some cases.