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某些病人单独用普鲁卡因酰胺(P)和奎尼丁(Q)治疗时,因用药量大,副作用严重而无法忍受。为此,作者评价了两种药物小量联合使用对19例连续病例的安全性和效力。方法男16例,女3例,平均年龄58±14岁,均有反复发作的室性心动过速(VT),为症状性室性心律失常并经动态心电图监测证实。14例为冠心病,5例为心肌病。先停用全部抗心律失常药物5个半衰期以上,给所有病人记录基础的24h 动态心电图。然后,口服 Q400mg,每6h 1次。若出现副作用则减量至副作用消失,若无出现副作用则可加量至副作用
Some patients treated with procainamide (P) alone and quinidine (Q), due to the large amount of medication, serious side effects can not tolerate. To this end, the authors evaluated the safety and efficacy of two small-drug combinations in 19 consecutive cases. Methods There were 16 males and 3 females, with an average age of 58 ± 14 years. All of them had recurrent ventricular tachycardia (VT). They were symptomatic ventricular arrhythmia and were confirmed by Holter monitoring. 14 cases of coronary heart disease, 5 cases of cardiomyopathy. Disable all anti-arrhythmic drugs for more than 5 half-lives and record 24-hour Holter for all patients. Then, oral Q400mg, every 6h 1 time. If the side effects are reduced to the side effects disappear, if no side effects can be added to the side effects