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脑脉通口服液（ 由制大黄、水蛭、川芎、三七、瓜蒌、石菖蒲、枳实、川朴、葛根等组成） 为山东中医药大学附属医院临床治疗急性缺血性中风的有效制剂。为探讨其药理学机制， 观察了不同剂量组脑脉通口服液对结扎大鼠双颈总动脉造成的不完全性脑缺血实验模型的保护作用。结果表明， 脑脉通可以减轻大鼠脑毛细血管通透性， 减轻脑水肿（ Ｐ＜０ ．０５ 或Ｐ＜ ０ ．０１） ； 延长断头小鼠脑功能维持时间（ Ｐ＜ ０ ．０５ 或Ｐ＜ ０．０１ ） ； 对二磷酸腺苷（ＡＤＰ） 诱发的大鼠血小板聚集及血栓性死亡呈拮抗作用（ Ｐ＜ ０．０５ 或Ｐ＜ ０．０１） 。本研究结果为脑脉通口服液临床治疗急性缺血性中风提供实验依据
Naomaitong oral liquid (consisting of rhubarb, leeks, Chuanxiong, Panax notoginseng, Gualou, Shichangpu, Citrus aurantium, Chuan Pu, Puerariae etc.) is an effective preparation for clinical treatment of acute ischemic stroke in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine. . In order to investigate its pharmacological mechanism, the protective effects of different dosages of Naomaitong oral liquid on ligation of incomplete cerebral ischemia caused by ligation of the common carotid artery in rats were observed. The results showed that Naomaitong could reduce the permeability of cerebral capillaries in rats, reduce cerebral edema (P<0.05 or P<0.01), and extend the duration of brain function maintenance in decapitated mice (P<0.05). P < 0.01 ) ; Antagonize the platelet aggregation and thromboembolic death induced by adenosine diphosphate (ADP) in rats (P < 0.05 or P <0.01). The results of this study provide experimental basis for the treatment of acute ischemic stroke with Naomaitong oral liquid