补体是由20余种蛋白质构成的一个复杂的限制性蛋白解(limited proteoIysis)系统,藉蛋白解作用可将没有活性的天然补体成份裂解激活,级联式地进行下去,发挥抗感染,免疫调控等作用,在某些情况下也可造成组织损伤等病理反应。补体的激活途径有两条,分别称为第一(经典)途径与第二(旁路)途径。在这两条激活途径中,有两个结构与功能类似的丝氨酸蛋白酶原,分别参与第一及第二途径途径活化的关键步骤——C3转化酶与C5转化酶的形成,前者为C2,后者即B因子。本文就后者的目前研究进展结合我们在这方面做的一点工作作一简略回顾。 Complement is a complex proteolytic system composed of more than 20 kinds of proteins. By proteolytic cleavage, inactive native complement components can be cleaved and activated by cascade, exerting anti-infective and immunological regulation And so on, in some cases can also cause tissue damage and other pathological reactions. There are two ways of complement activation, called the first (classic) pathway and the second (bypass) pathway. In these two activation pathways, two serine proteases with similar structure and function are involved in the formation of the first and second pathway pathway activation, C3 convertase and C5 convertase, the former is C2, and the latter Who is the B factor. This article reviews the latter’s current research and a brief review of some of the work we have done in this area.