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黄尿酸是动物体内的色氨酸代谢产物。当维生索B6缺乏时,黄尿酸排泄量既显著增多[1,2]。因此,可在色氨酸负荷给药的情况下行黄尿酸排泄量测定,作为诊断维生秦B_6缺乏症的一个可靠的专一性指标[3]。近年曾有人证明,若干酰肼化合物可致色氨酸负荷动物的黄尿酸排泄增加,从而认为酰肼可导致实验性维生素B_6缺乏症[4-6]。本实验既在证实硫氨脲、异菸肼及硫酸肼在色氨酸负荷下的家兔对黄尿酸排泄的影响,为酰肼化合物引起维生素B_6缺乏症作进一步的证明。
Yellow uric acid is a tryptophan metabolite in animals. When vitamin B6 is deficient, there is a significant increase in excretion of flavonoids [1,2]. Therefore, the determination of excretion of uric acid can be performed in the case of tryptophan loading, as a reliable and specific indicator for diagnosis of vitamin B 6 deficiency [3]. In recent years, it has been demonstrated that several acylhydrazine compounds can cause increased tryptophan-loaded animals excretion of uric acid, which that hydrazide can lead to experimental vitamin B_6 deficiency [4-6]. This experiment not only confirms the influence of thiourea, isoniazid and hydrazine sulfate on the excretion of flavonoids in rabbits under the tryptophan load, further proving the vitamin B_6 deficiency caused by hydrazide compounds.