黄酮是具有多种生物活性的一大类天然物质,尤其槲皮黄酮(3,3’,4’,5,7-五羟基黄酮,quercetin,简称Q)对人的白血病细胞及几种人癌细胞系的增殖具有强大抑制作用。Q的抗增殖活性是通过所谓的Ⅱ型雌激素结合位点(type ⅡEBSs)介导的。实验使用MCF-7的变异株,即抗阿霉素的雌激素受体负性人乳腺癌细胞系(MCF-7 ADRr),用6,7-氚([~3H]-E2)标记雌二醇作为示踪剂进行完整的细胞试验。结果证实, Flavonoids are a large group of natural substances with a variety of biological activity, especially quercetin (abbreviated as Q), of quercetin (Q, Q) on human leukemia cells and several human cancers Cell proliferation has a strong inhibitory effect. The antiproliferative activity of Q is mediated through so-called type II estrogen binding sites (type II EBSs). Experiments were performed using a mutant strain of MCF-7, an estrogen receptor negative human breast cancer cell line (MCF-7 ADRr) resistant to doxorubicin, estradiol Alcohol as a tracer for a complete cell assay. The results confirm that,