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作者复习了部分文献记载的出现异丙基肾上腺素副作用的病例,并在自己的病历记录中查出8例患者使用本药治疗剂量时发生毒性反应,这些病人中2例发生急性心肌梗死,伴有心动过速、胸骨后疼痛、低血压、血清酶的变化等符合心肌梗死的症状,心电图检查可见心前区导联S-T段明显下降,其中1例死于异丙基肾上腺素诱发的缺血性发作。1例(3岁、女)于心脏外科手术后使用本药静脉滴注,出现可逆性的心内膜下缺血,S-T段明显下降,停止静滴后恢复正常。其余5例包括支气管哮喘的患者,心电图表现为异常的S-T段下降,证实有一时性的心肌缺血,这些患者的特征性胸痛可随着停止异丙基肾上腺素治疗、舌下含服硝酸甘油和吸氧而缓解。作者认为心电图是反映异丙基肾上腺素毒性反应的一个可靠而敏感的方法。在使用过程中要观察S-T
The authors reviewed some of the documented cases of isoproterenol side effects and found in their medical history records that 8 patients developed toxic reactions when treated with this drug and 2 of these patients developed acute myocardial infarction with Tachycardia, post-sternal pain, hypotension, changes in serum enzymes in line with myocardial infarction symptoms, ECG showed pre-anterior leads ST segment decreased significantly, of which 1 died of isoproterenol-induced ischemia Sexual attack. One patient (3 years old, female) underwent IV cardioversion after cardiological surgery. Reversible subendocardial ischemia occurred. The S-T segment was significantly decreased and stopped returning to normal after intravenous infusion. The remaining 5 patients including bronchial asthma, ECG showed abnormal ST-segment decline, confirmed a temporary myocardial ischemia, these patients with characteristic chest pain can be stopped with isoproterenol treatment, sublingual nitroglycerin And oxygen and ease. The authors believe that electrocardiography is a reliable and sensitive method of reflecting the toxicity of isoproterenol. In the process of using to observe S-T