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本文利用多种心律失常的动物模型研究603(盐酸N-(β-二乙胺乙基)-N-邻甲苯基-3,4,5-三甲氧基苯甲酰胺)的抗心律失常作用。 在改良的Lawson小鼠氯仿模型中,腹腔注射603的治疗指数(LD_(50)/ED_(50))和安全范围(LD_5/ED_(95))分别为3.38和1.87,与奎尼丁和茚丙胺相近似,而稍逊于利多卡因。在大鼠乌头碱模型中,603恒速注射的有效量为9.1±2.0mg/kg,治疗指数(最小致死量/最小有效量)为22.5,而利多卡因的有效量为30±6.6mg/kg,治疗指数仅为2.6。603灌服200mg/kg也有预防乌头碱诱发心律失常的作用。在狗哇巴因模型中,603的有效量为10.1±3.3 mg/kg,利多卡因则为31.1±22mg/kg。实验结果表明,603的抗心律失常作用优于利多卡因,且在个体中的差异较小,所用剂量也易于控制。
In this paper, the anti-arrhythmic effect of 603 (N- (β-diethylaminoethyl) -N-o-tolyl-3,4,5-trimethoxybenzamide hydrochloride) was investigated in animal models of various arrhythmias. The therapeutic index (LD50 / ED50) and safety margin (LD5 / ED95) of 603 in peritoneal injection were 3.38 and 1.87 in modified Lawson mouse chloroform model, respectively, with quinidine and indene Propylamine is similar, but less than lidocaine. In the rat aconitine model, an effective amount of 603 constant-rate injection was 9.1 ± 2.0 mg / kg, a therapeutic index (minimum lethal dose / minimum effective dose) was 22.5, and an effective amount of lidocaine was 30 ± 6.6 mg / kg, the treatment index was only 2.6.603 Filling 200mg / kg also have the effect of preventing aconitine induced arrhythmia. In the dog ouabain model, the effective amount of 603 was 10.1 ± 3.3 mg / kg and the lidocaine was 31.1 ± 22 mg / kg. The experimental results show that the anti-arrhythmic effect of 603 is superior to lidocaine, and the difference in the individual is small, the dose used is also easy to control.