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目的:探讨胰岛素联合百令胶囊对早期糖尿病肾病患者临床疗效的影响。方法:选取前来我院就诊的已确诊的早期糖尿病肾病患者70例,随机分为对照组和治疗组,每组35例。对照组给予门冬胰岛素治疗;治疗组在对照组基础上联合百令胶囊。比较治疗前后两组患者的血糖、尿白蛋白排泄率(UAER)、24 h尿蛋白定量、β2—微球蛋白(β2-MG)、血肌酐(SCr)、尿素氮(BUN)、T淋巴细胞(CD68)水平的变化情况,记录分析两组患者的临床疗效。结果:治疗组总有效率明显高于对照组(P<0.05)。治疗后,两组患者血糖、UAER、24h尿蛋白定量、β2-MG、SCr、BUN、CD68水平均较治疗前显著降低,且治疗组低于对照组(P<0.05)。结论:胰岛素和百令胶囊的联合应用能有效控制早期糖尿病肾病患者的血糖水平,减少肾脏损伤,缓解临床症状,提高临床疗效。
Objective: To investigate the effect of insulin combined with Bailing capsule on the clinical efficacy of patients with early diabetic nephropathy. Methods: Seventy patients with diagnosed early diabetic nephropathy who came to our hospital were randomly divided into control group and treatment group, 35 cases in each group. The control group was treated with insulin aspart and the treatment group was combined with Bailing capsule on the basis of the control group. Blood glucose, urinary albumin excretion rate (UAER), 24 h urinary protein, β2-MG, SCr, BUN and T lymphocytes were compared between the two groups before and after treatment. (CD68) levels of changes, record the clinical efficacy of two groups of patients. Results: The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). After treatment, the levels of blood glucose, UAER, 24h urinary protein, β2-MG, SCr, BUN and CD68 in both groups were significantly lower than those before treatment, and the treatment group was lower than the control group (P <0.05). Conclusion: The combined application of insulin and Bailing Capsule can effectively control the blood glucose level of patients with early diabetic nephropathy, reduce renal damage, relieve clinical symptoms and improve clinical efficacy.