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目的:探讨胃癌术后早期腹腔持续温热灌注化疗的临床意义。方法:将1998-2001年收治的胃癌手术患者的随机分成术后早期腹腔持续温热灌注化疗组及对照组,治疗后随访3年,对比两组的治疗效果。结果:比较两组的局部复发率、远处转移率及3年生存率等指标,Ⅰ期胃癌无显著差异;Ⅱ期、Ⅲ期、Ⅳ期胃癌有显著差异。肿瘤未浸润至浆膜的胃癌无显著差异;浸润至浆膜的胃癌有显著差异。结论:Ⅱ期、Ⅲ期、Ⅳ期胃癌及肿瘤浸润至浆膜的胃癌术后早期腹腔持续温热灌注化疗可减少局部复发率和远处转移率,提高3年生存率。Ⅰ期及病变未浸润至浆膜的胃癌可不必常规行术后早期腹腔持续温热灌注化疗。
Objective: To investigate the clinical significance of early peritoneal hyperthermic perfusion chemotherapy of gastric cancer after operation. Methods: The gastric cancer patients admitted from 1998 to 2001 were randomly divided into continuous hyperthermic perfusion chemotherapy group and control group. The patients were followed up for 3 years. The therapeutic effect was compared between the two groups. Results: The local recurrence rate, distant metastasis rate and 3-year survival rate were compared between the two groups. There was no significant difference in stage I gastric cancer. There were significant differences in stage II, stage III and stage IV gastric cancer. Tumors did not infiltrate into the serosa of gastric cancer no significant difference; infiltration of gastric serosa were significantly different. CONCLUSIONS: Early stage peritoneal hyperthermic perfusion chemotherapy of gastric cancer with stage Ⅱ, Ⅲ, Ⅳ gastric cancer and gastric tumor invasion to serosa can reduce the local recurrence rate and distant metastasis rate and improve the 3-year survival rate. Stage Ⅰ and lesions not infiltrated into the serosa of the gastric cancer may not routinely follow the early postoperative continuous intraperitoneal hyperthermic perfusion chemotherapy.