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目的探讨羟乙基淀粉和丁苯酞软胶囊治疗进展性脑卒中的疗效。方法将75例进展性脑卒中患者随机分为试验组(38例)和对照组(37例)。对照组给予羟乙基淀粉250ml静脉滴注,每天1次;试验组给予丁苯酞软胶囊200mg口服,每天3次;疗程均为28d。比较两组患者的疗效。结果治疗7、14和28d后,两组临床神经功能缺损量表评分均较治疗前下降(P<0.05),但两组间无统计学差异(P>0.05)。试验组和对照组治疗有效率无统计学差异(92.11%vs.89.19%)(P>0.05)。治疗28d后,两组日常生活活动能力量表评分均较治疗前升高(P<0.05),但两组间无统计学差异(P>0.05)。结论羟乙基淀粉和丁苯酞软胶囊治疗进展性脑卒中均有效。
Objective To investigate the efficacy of hydroxyethyl starch and butylphthalide soft capsules in patients with advanced stroke. Methods 75 patients with progressive stroke were randomly divided into experimental group (38 cases) and control group (37 cases). Control group was given hydroxyethyl starch 250ml intravenous infusion, once a day; test group given butylphthalide soft capsule 200mg orally, 3 times a day; treatment were 28d. Compare the efficacy of two groups of patients. Results After 7, 14 and 28 days of treatment, the score of clinical neurological deficit scale in both groups decreased compared with that before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). There was no significant difference between the experimental group and the control group (92.11% vs.89.19%) (P> 0.05). After 28 days of treatment, scores of activities of daily living in both groups were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion Hydroxyethyl starch and butylphthalide soft capsules are effective in treating progressive stroke.