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目的:分别测定葛根芩连汤煎剂和葛根单煎剂中葛根素(Puerarin)在家犬血清中的含量,分析不同煎煮方式对其体内药动学的影响。方法:通过测定不同时刻家犬体内葛根素浓度,计算药动学参数。结果:家犬灌服葛根芩连汤煎剂和葛根单煎剂后葛根素在家犬体内的Cmax分别(5.164±0.637)、(5.383±0.818)μg/mL;tmax分别为(1.10±0.374)和(1.25±0.274)h;AUC0～t分别为(25.76±5.48)、(27.97±7.16)μg/(mL.h)。结论:煎煮方式对葛根素家犬体内药动学有显著影响。
Objective: To determine the content of Puerarin in Puerarin decoction and Puerarin Decoction in dogs respectively, and analyze the influence of different decocting methods on its pharmacokinetics. Methods: Pharmacokinetic parameters were calculated by determining the concentration of puerarin in dogs at different time points. Results: The C max values of puerarin were (5.164 ± 0.637) and (5.383 ± 0.818) μg / mL, respectively, in dogs fed Gegen Qinlian decoction and Pueraria decoction; tmax were (1.10 ± 0.374) and (1.25 ± 0.274) h; AUC0 ~ t were (25.76 ± 5.48) and (27.97 ± 7.16) μg / (mL.h), respectively. Conclusion: The decoction method has a significant effect on the pharmacokinetics of puerarin dogs.