人外周血 T 克隆细胞在 YIL-2持续刺激下具有良好的体外扩增能力和LAK 活性。在半固体琼脂培养体系中,T 克隆细胞抑制骨髓 CFU-GM 形成,抑制效应与 T 细胞数量、T 细胞和骨髓细胞的预孵育时间呈正相关。自体及异体 T 克隆细胞对 CFU-GM 的抑制作用无显著差异。经 FACS 表型分析,这种 IL-2激活的 T 克隆细胞为T_3(+)、T_4(-)、T_8(+)、DR(+)、Tac(+)。 Human peripheral blood T clonal cells have good in vitro expansion ability and LAK activity under the continuous stimulation of YIL-2. In the semi-solid agar culture system, T cells inhibited the formation of CFU-GM in bone marrow. The inhibitory effect was positively correlated with the number of T cells and the preincubation time of T cells and myeloid cells. There was no significant difference in the inhibition of CFU-GM between autologous and allogeneic T cell clones. According to the FACS phenotype analysis, the T cells (T_3), T_4 (-), T_8 (+), DR (+) and Tac (+) activated by IL-