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目的观察被动吸烟对小鼠白介素-6(IL-6)、白介素-8(IL-8)水平表达的影响。方法将小鼠随机分为2组,分别为实验组和对照组。用ELISA方法检测小鼠血清中IL-6、IL-8的表达情况。结果实验组小鼠血清中IL-6含量为(41.77±1.87)pg/ml,对照组小鼠血清中IL-6含量为(34.98±1.84)pg/ml,两者相比,差异有统计学意义(t=14.15,P<0.01)。实验组小鼠血清中IL-6含量增高;实验组小鼠血清中IL-8含量为(52.95±1.09)pg/ml,对照组小鼠血清IL-8含量为(65.63±2.59)pg/ml,两者相比差异有统计学意义(t=24.86,P<0.01)。实验组小鼠血清中IL-8含量减少。结论被动吸烟能促使小鼠IL-6的表达升高,IL-8的表达降低。可能与其参与炎症反应过程有关。
Objective To observe the effect of passive smoking on the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) in mice. Methods The mice were randomly divided into two groups, experimental group and control group. The serum levels of IL-6 and IL-8 in mice were detected by ELISA. Results The serum level of IL-6 in the experimental group was (41.77 ± 1.87) pg / ml, while that in the control group was (34.98 ± 1.84) pg / ml. There was significant difference between the two groups Significance (t = 14.15, P <0.01). The level of IL-6 in the serum of experimental mice increased (52.95 ± 1.09) pg / ml and that of control mice was (65.63 ± 2.59) pg / ml , There was significant difference between the two (t = 24.86, P <0.01). Experimental group mice serum IL-8 content decreased. Conclusion Passive smoking can promote the expression of IL-6 and decrease the expression of IL-8 in mice. May be involved in the inflammatory response process.