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目的探讨新疆哈萨克族和汉族高血压患者血清游离脂肪酸(FFA)、胰岛素抵抗(IR)与高血压的关系。方法随机抽取哈萨克族161例和汉族136例高血压患者为高血压组,154例哈萨克族和140例汉族健康个体为对照组,采用比色法测定FFA浓度,用放射免疫法测定空腹胰岛素(FINS)浓度,并计算胰岛素抵抗指数(HOMA-IR)。结果①哈萨克族和汉族高血压组FFA、HOMA-IR水平显著高于同民族对照组[哈萨克族:FFA(0.63±0.23)比(0.51±0.21),P<0.01;HOMA-IR(4.11±3.82)比(2.46±2.75),P<0.01);汉族:FFA(0.57±0.29)比(0.47±0.18),P<0.01;HOMA-IR(3.59±3.23)比(1.93±1.58),P<0.01]。②采用多因素logistic回归分析,在调整了性别、年龄、吸烟、饮酒后,FFA和HOMA-IR与哈萨克族和汉族高血压的发生都相关。③HOMA-IR与哈萨克族和汉族收缩压、三酰甘油、体质量指数(BMI)和高密度脂蛋白胆固醇(HDL-C)均有相关性,FFA与汉族空腹血糖、低密度脂蛋白胆固醇以及哈萨克族空腹血糖、总胆固醇、BMI有相关性(均P<0.05)。结论 FFA和IR可能是新疆哈萨克族高血压的独立危险因素,并且在较低的FFA和HOMA-IR水平就有可能对哈萨克族人群高血压的发生产生影响。
Objective To investigate the relationship between serum free fatty acid (FFA), insulin resistance (IR) and hypertension in Kazak and Han Chinese patients with hypertension. Methods A total of 161 Kazaks and 136 Han Chinese hypertensive patients were randomly divided into hypertension group, 154 Kazaks and 140 Han healthy individuals. The concentrations of FFA were determined by colorimetric method. The levels of fasting insulin (FINS) ) Concentration, and calculate the insulin resistance index (HOMA-IR). Results ① The levels of FFA and HOMA-IR in Kazak and Han patients were significantly higher than those in the same nationality [Kazaks: FFA (0.63 ± 0.23) vs (0.51 ± 0.21), P <0.01; HOMA-IR was 4.11 ± 3.82 (2.46 ± 2.75, P <0.01); Han: FFA (0.57 ± 0.29) ratio (0.47 ± 0.18), P <0.01; HOMA-IR ]. (2) Multivariate logistic regression analysis showed that FFA and HOMA-IR were related to the occurrence of hypertension in Kazakh and Han after adjustment for gender, age, smoking and drinking. HOMA-IR was correlated with systolic blood pressure, triglyceride, body mass index (BMI) and high density lipoprotein cholesterol (HDL-C) in Kazakh and Han nationality. FFA was associated with fasting blood glucose, low density lipoprotein cholesterol, Family fasting blood glucose, total cholesterol, BMI were related (all P <0.05). Conclusions FFA and IR may be independent risk factors for hypertension in Kazaks in Xinjiang and may affect the incidence of hypertension in Kazaks at lower FFA and HOMA-IR levels.