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目的探讨金关片对大鼠痛风性关节炎的药效作用。方法采用尿酸钠晶体制备大鼠痛风性关节炎模型,分别测量大鼠足肿胀度,血清中尿酸(UA)和一氧化氮(NO)的水平及大鼠踝关节软组织中炎症因子(IL-1、IL-6、TNF-α)的含量。结果金关片能显著降低痛风性关节炎模型大鼠踝关节的容积(P<0.05、P<0.01),降低血清中UA、NO的水平(P<0.05、P<0.01)以及关节软组织中IL-1、IL-6、TNF-α的水平(P<0.05、P<0.01)。结论金关片对大鼠痛风性关节炎具有防治作用,其抗炎的机制可能与其降低炎症组织中IL-1、IL-6、TNF-α的含量,减轻其炎症损害有关。
Objective To explore the effect of Jin Guan Tablet on gouty arthritis in rats. Methods The rat model of gouty arthritis was prepared by sodium urate crystal. The degree of paw edema, serum uric acid (UA) and nitric oxide (NO) levels and inflammatory cytokines (IL-1 , IL-6, TNF-α). Results Gold tablets can significantly reduce the ankle joint volume (P <0.05, P <0.01), decrease the levels of UA and NO in serum (P <0.05, P <0.01) -1, IL-6 and TNF-α (P <0.05, P <0.01). Conclusion Jin Guan Pian has a preventive and therapeutic effect on gouty arthritis in rats. The mechanism of anti-inflammation may be related to the decrease of the content of IL-1, IL-6 and TNF-α in inflammatory tissue and the alleviation of inflammatory damage.