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目的研究医院获得性下呼吸道感染的铜绿假单胞细胞,对目前临床常用的17种抗菌药物的敏感性和耐药性,并进一步探讨其耐药机制。方法对我医院下呼吸道感染分离出的618株铜绿假单胞菌的药敏试验进行回顾性分析。结果618株铜绿假单胞菌对17种抗菌药物的平均敏感率为47.29%,平均耐药率为52.71%,对9种以上抗生素耐药者占51.9%。敏感率最高的为多粘菌素B为100%,其他依次减少的头孢哌酮/舒巴坦78.3%,头孢他啶72.8%,亚安培南68.0%,阿米卡星66.9%等。结论铜绿假单胞菌是医院下呼吸道感染常见致病菌之一,其耐药问题已十分突出,有321株多种抗生素耐药株,并出现多种耐药机制。多种抗生素耐药株的危害性应引起临床医生的高度重视。
Objective To study the sensitivity and drug resistance of Pseudomonas aeruginosa cells derived from hospital-acquired lower respiratory tract infection to 17 kinds of antibacterial drugs commonly used in clinic at present, and to further explore its mechanism of drug resistance. Methods The susceptibility test of 618 strains of Pseudomonas aeruginosa isolated from our hospital lower respiratory tract infection was retrospectively analyzed. Results The average susceptibilities of 618 strains of Pseudomonas aeruginosa to 17 kinds of antibiotics were 47.29%, 52.71% and 51.9% respectively. The highest sensitive rate was that of polymyxin B was 100%, followed by other cefoperazone / sulbactam 78.3%, ceftazidime 72.8%, ianamipene 68.0% and amikacin 66.9%. Conclusions Pseudomonas aeruginosa is one of the common pathogenic bacteria in lower respiratory tract infection in hospitals. The resistance of Pseudomonas aeruginosa is very prominent. There are 321 multi-antibiotic resistant strains with multiple drug resistance mechanisms. A variety of antibiotic-resistant strains of harmful should be caused by clinicians attach great importance.