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目的:比较脑神经生长素(CNG)与胞磷胆碱(Cit)治疗急性脑出血所致神经功能障碍的疗效。方法:CNG组56例[男性32例,女性24例;年龄(61±s5)a],病程(3.8±1.5)d;出血量(20.5±2.3)mL;用CNG2~4mL,im,qd,用药10~20d者30例,21~30d者26例。Cit组60例[男性38例,女性22例;年龄(59±9)a],病程(3.5±1.7)d;出血量(19.3±2.8)mL;Cit500mg于5%葡萄糖注射液500mL中静脉滴注,qd,用药10~20d者24例,21~30d者36例。结果:CNG组与Cit组显效率分别为73%和54%(P<0.05),未见明显不良反应。结论:CNG是治疗急性期脑出血所致神经功能障碍安全有效的新药
Objective: To compare the efficacy of cranial nerve growth factor (CNG) and citicoline (Cit) in the treatment of neurological dysfunction caused by acute cerebral hemorrhage. Methods: 56 cases in CNG group (32 males and 24 females; age (61 ± s5) a], course of disease (3.8 ± 1.5) d, bleeding volume (20.5 ± 2.3) mL; CNG 2 ~ 4mL, im, qd, medication 10 ~ 20d in 30 cases, 21 ~ 30d in 26 cases. Cit group 60 cases [38 males and 22 females; age (59 ± 9) a], course of disease (3.5 ± 1.7) d, bleeding volume (19.3 ± 2.8) mL; Cit500mg in 5 % Glucose injection 500mL intravenous drip, qd, medication 10 ~ 20d in 24 cases, 21 ~ 30d in 36 cases. Results: The markedly effective rates of CNG group and Cit group were 73% and 54% respectively (P <0.05), and no obvious adverse reactions were found. Conclusion: CNG is a safe and effective new drug for the treatment of neurological dysfunction caused by cerebral hemorrhage in acute stage