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目的探讨活血消瘿片治疗缺碘性甲状腺肿模型大鼠及对其甲状腺功能的影响。方法选取通过触诊与甲状腺彩超结合确定为缺碘性甲状腺肿的大鼠100只,采用随机数字表将所有大鼠分成五组,随机分为实验组和对照组,即模型组和正常组(不予以任何药品)、活血消瘿片组(予以活血消瘿片粉剂)、优甲乐组(予以甲乐组溶液)及联合用药组(同时予以活血消瘿片粉剂和甲乐组溶液)。检测各组患者的甲状腺重量和甲状腺功能。结果与模型组比较,优甲乐组和活血消瘿片组甲状腺重量均有所下降,且活血消瘿片组下降幅度更明显(P<0.05),但与优甲乐组比较,活血消瘿片并无明显消肿作用,而联合用药组的治疗效果明显强于其他各组(P<0.05);与模型组比较,优甲乐组有明显治疗效果,但相对于优甲乐组而言,活血消瘿片对甲状腺功能的影响较小(P<0.05)。结论活血消瘿片对缺碘性甲状腺肿具有一定的治疗效果,可升高FT_3和FT_4,降低TSH,但不良影响较小,在临床治疗中具有重要意义。
Objective To investigate the effect of Huoxue Xiaobian Tablet on iodine-deficient goiter model rats and its thyroid function. Methods A total of 100 rats with iodine deficiency goiter were selected by palpation and thyroid ultrasonography. All the rats were divided into five groups by random number table and randomly divided into experimental group and control group, namely, model group and normal group Not to be any drugs), Huoxue Xiaodi tablets group (to be Huoxue Xiandan tablets powder), Euthyrox group (to be A group solution) and combination group (at the same time Huoxue Xiandan powder and Jiale group solution). Thyroid weight and thyroid function were examined in each group. Results Compared with the model group, the thyroid weight of both Euthyrox group and Huoxuexiao Tablet group decreased, and the decrease of Huoxuaxiao Tablet group was more significant (P <0.05). However, compared with Euthyrox group, There was no obvious swelling effect in the combination group, but the combination treatment group was significantly better than the other groups (P <0.05). Compared with the model group, the Euthyrox group had obvious therapeutic effect, but compared with the Euthyrox group , Huoxuexiao tablet on the thyroid function was less (P <0.05). Conclusion Huoxue Xiaobian Tablet has a certain therapeutic effect on iodine deficiency goiter, can increase FT_3 and FT_4, reduce TSH, but less adverse effects in the clinical treatment of great significance.